The desired product of whole-genome sequencing (WGS) is a catalog of all genetic variants within a given sample. Although motivations may be different, most healthcare and life science organization share a common goal: minimizing the time and cost to generate this catalog of variants. Research organizations competing for grant awards must be competitive on the time and costs for generating the most comprehensive variant catalog possible. To recognize revenue, a sequencing service provider must return a list of variants to its customer per agreed-on timelines. All the while, they must contain costs to maximize their returns. While in a clinical setting, a diagnostic variant report is needed at a level of accuracy and speed that impacts the care of a patient.
