If your business requirements including supporting Cloud Foundation on VxRail across multiple regions, there are additional preparation steps that are required.
In a multi-region deployment with NSX Federation, one region is selected as the global manager for the NSX Federation. The NSX Local Managers in each region connect with the NSX global manager in the selected region. The global manager provides the administration support for NSX global objects across the regions.
You can also configure two regions to support global management to support active/standby failover configuration, but at least one must be selected for this purpose. The size of the virtual machines that must be deployed in the management domain selected for global management depends on the size of the multi-region NSX federation. See Appendix B: Cloud Foundation on VxRail footprints for sizing for guidance on sizing the virtual machines in the VCF management domain.