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macOS 11.3 adds SMB3 multichannel support as described in Apple KB HT212277. Apple outlines a couple of settings to multichannel behavior that can be changed with /etc/nsmb.conf. One such setting is to force multichannel to prefer wired connections. Due to the possible negative performance impacts of using Wi-Fi with SMB multichannel, it is recommended to force macOS to prefer wired connections.
To force macOS 11.3 to prefer wired connections for SMB multichannel, add the following line to /etc/nsmb.conf.
mc_prefer_wired=yes