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Dell Technologies recommends configuring ESXi with Round Robin Path Selection Plug-in with IOPS limit of 1. See VMware Knowledge Base article 2069356 -- https://kb.vmware.com/kb/2069356
When configuring LUNs on ESXi that are accessed via iSCSI, disable “DelayedACK” on ESXi. See VMware Knowledge Base article 1002598 -- http://kb.vmware.com/kb/1002598
When creating NFS-based storage for ESXi, Dell Technologies recommends creating VMware NFS Datastores instead of general-purpose NFS file systems. VMware NFS Datastores are optimized to provide better performance with ESXi. Install the VAAI plug-in before creating NFS Datastores, to enable these optimizations. When creating VMware NFS Datastores, Dell Technologies recommends using the default 8K Host IO Size. Only choose a different Host IO Size if all applications that will be hosted in the NFS Datastore primarily use the selected I/O size.
When configuring vVol NFS Datastores, it is recommended to create at least 2 vVol-enabled NAS Servers, 1 on SPA and 1 on SPB.