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Multipathing (MPIO) is critical to achieving the best performance from VMware hosts and should be configured properly. Apply VMware MPIO best practices by following the guidance in the document Dell PowerVault: VMware vSphere Best Practices on the Dell Technologies Storage Info Hub.
Using iSCSI for block storage allows convergence of storage and networking infrastructure though it does require careful planning for bandwidth requirements and fault isolation. Redundant networks are preferred for data availability.
With iSCSI, Jumbo frames are also recommended. They allow greater packet efficiency for higher bandwidth. Using Jumbo frames is not a requirement but should be considered. Combined with the 25 GbE connectivity available in PowerVault, iSCSI can handle demanding workloads and high throughput requirements.
Use of 16/32 Gb FC is also supported. Dual fabrics are recommended for redundancy.